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Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
Russell, Stephanie; Rahmani, Raphaël; Jones, Amy J; Newson, Harriet L; Neilde, Kevin; Cotillo, Ignacio; Rahmani Khajouei, Marzieh; Ferrins, Lori; Qureishi, Sana; Nguyen, Nghi; Martinez-Martinez, Maria S; Weaver, Donald F; Kaiser, Marcel; Riley, Jennifer; Thomas, John; De Rycker, Manu; Read, Kevin D; Flematti, Gavin R; Ryan, Eileen; Tanghe, Scott; Rodriguez, Ana; Charman, Susan A; Kessler, Albane; Avery, Vicky M; Baell, Jonathan B; Piggott, Matthew J.
  • Russell S; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.
  • Rahmani R; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.
  • Jones AJ; Eskitis Institute for Drug Discovery, Griffith University , Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia.
  • Newson HL; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.
  • Neilde K; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.
  • Cotillo I; GlaxoSmithKline , 28760 Tres Cantos, Spain.
  • Rahmani Khajouei M; GlaxoSmithKline , 28760 Tres Cantos, Spain.
  • Ferrins L; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.
  • Qureishi S; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.
  • Nguyen N; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.
  • Martinez-Martinez MS; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.
  • Weaver DF; GlaxoSmithKline , 28760 Tres Cantos, Spain.
  • Kaiser M; Department of Chemistry, Dalhousie University , Halifax Nova Scotia B3H 4R2, Canada.
  • Riley J; Swiss Tropical and Public Health Institute , Socinstrasse, 4051 Basel, Switzerland.
  • Thomas J; University of Basel , Petesplatz 1, 4003 Basel, Switzerland.
  • De Rycker M; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , DD1 5EH Dundee, U.K.
  • Read KD; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , DD1 5EH Dundee, U.K.
  • Flematti GR; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , DD1 5EH Dundee, U.K.
  • Ryan E; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , DD1 5EH Dundee, U.K.
  • Tanghe S; School of Chemistry and Biochemistry, The University of Western Australia , 35 Stirling Highway, Crawley, Perth 6009, Western Australia, Australia.
  • Rodriguez A; Centre for Drug Candidate Optimisation, Monash University , Parkville, Victoria 3052, Australia.
  • Charman SA; Anti-Infectives Screening Core, New York University School of Medicine , New York, New York 10010, United States.
  • Kessler A; Anti-Infectives Screening Core, New York University School of Medicine , New York, New York 10010, United States.
  • Avery VM; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.
  • Baell JB; Centre for Drug Candidate Optimisation, Monash University , Parkville, Victoria 3052, Australia.
  • Piggott MJ; GlaxoSmithKline , 28760 Tres Cantos, Spain.
J Med Chem ; 59(21): 9686-9720, 2016 11 10.
Article en En | MEDLINE | ID: mdl-27548560
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Banco de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Trypanosoma cruzi / Descubrimiento de Drogas / Inhibidores de 14 alfa Desmetilasa Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article
Search on Google
Imprimir
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PubMed Links

Banco de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma brucei brucei / Trypanosoma cruzi / Descubrimiento de Drogas / Inhibidores de 14 alfa Desmetilasa Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article