Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon.
Int Rev Cell Mol Biol
; 326: 279-341, 2016.
Article
en En
| MEDLINE
| ID: mdl-27572131
ABSTRACT
Glucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein-coupled receptors (GPCRs). They are key regulators of hormonal homeostasis and are important drug targets for metabolic disorders such as type-2 diabetes mellitus (T2DM), obesity, and dysregulations of the nervous systems such as migraine, anxiety, depression, neurodegeneration, psychiatric disorders, and cardiovascular diseases. The current review aims to provide a detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members within this family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Glucagón
/
Polipéptido Inhibidor Gástrico
/
Péptido 1 Similar al Glucagón
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Año:
2016
Tipo del documento:
Article