Plasticity of Cell Migration In Vivo and In Silico.
Annu Rev Cell Dev Biol
; 32: 491-526, 2016 10 06.
Article
en En
| MEDLINE
| ID: mdl-27576118
ABSTRACT
Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. Mechanistic principles that determine single-cell and collective migration modes and their interconversions depend upon the polarization, adhesion, deformability, contractility, and proteolytic ability of cells. Cellular determinants of cell migration respond to extracellular cues, including tissue composition, topography, alignment, and tissue-associated growth factors and cytokines. Both cellular determinants and tissue determinants are interdependent; undergo reciprocal adjustment; and jointly impact cell decision making, navigation, and migration outcome in complex environments. We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis.
Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Simulación por Computador
/
Movimiento Celular
/
Plasticidad de la Célula
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article