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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Rech, Jason C; Bhattacharya, Anindya; Branstetter, Bryan J; Love, Christopher J; Leenaerts, Joseph E; Cooymans, Ludwig P; Eckert, William A; Ao, Hong; Wang, Qi; Chaplan, Sandra R; Wickenden, Alan D; Lebsack, Alec D; Breitenbucher, J Guy.
  • Rech JC; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States. Electronic address: jrech2@its.jnj.com.
  • Bhattacharya A; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Branstetter BJ; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Love CJ; Janssen Pharmaceutical Research & Development L.L.C., Turnhoutseweg 30, Beerse, Belgium.
  • Leenaerts JE; Janssen Pharmaceutical Research & Development L.L.C., Turnhoutseweg 30, Beerse, Belgium.
  • Cooymans LP; Janssen Pharmaceutical Research & Development L.L.C., Turnhoutseweg 30, Beerse, Belgium.
  • Eckert WA; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Ao H; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Wang Q; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Chaplan SR; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Wickenden AD; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Lebsack AD; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
  • Breitenbucher JG; Janssen Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, United States.
Bioorg Med Chem Lett ; 26(19): 4781-4784, 2016 10 01.
Article en En | MEDLINE | ID: mdl-27595421
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinolinas / Antagonistas del Receptor Purinérgico P2X Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinolinas / Antagonistas del Receptor Purinérgico P2X Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article