Cellular Metabolism and Induced Pluripotency.
Cell
; 166(6): 1371-1385, 2016 Sep 08.
Article
en En
| MEDLINE
| ID: mdl-27610564
ABSTRACT
The discovery of induced pluripotent stem cells (iPSCs) a decade ago, which we are celebrating in this issue of Cell, represents a landmark discovery in biomedical research. Together with somatic cell nuclear transfer, iPSC generation reveals the remarkable plasticity associated with differentiated cells and provides an unprecedented means for modeling diseases using patient samples. In addition to transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompanied by a rewiring of metabolic pathways, which ultimately leads to changes in cell identities.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Redes y Vías Metabólicas
/
Células Madre Pluripotentes Inducidas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article