Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes.
Women Health
; 57(8): 891-904, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-27617395
ABSTRACT
The aim of the authors of this study was to clarify the relationships among apolipoprotein E (ApoE) genotype, blood pressure, lipid profile, serum leptin, and adiponectin in healthy postmenopausal women. The study was conducted between March 2011 and December 2012 on 266 participants aged 50-65 years from the Institute of Rural Health in Lublin, Poland. Results showed that women had four combinations of genotypes É2/É3, É3/É3, É3/É4, and É4/É4. Carriers of different genotypes did not differ in terms of age, body mass index (BMI), blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, and adiponectin levels. Mean low-density lipoprotein (LDL) cholesterol levels were higher in ε4 carriers compared to non-carriers. Fasting serum leptin concentrations were higher in homozygotes É4/É4. Leptin correlated positively with BMI in all study groups and with LDL in É2/É3, É3/É3, and É3/É4. Adiponectin correlated negatively with triglycerides in É2/É3, É3/É3, and É3/É4 and positively with HDL in É2/É3 carriers. Adipokines were not associated with blood pressure. Multiple regression analyses demonstrated associations among leptin, ApoE É4/É4, BMI, and LDL, and among adiponectin, BMI, and triglycerides. In healthy postmenopausal women É4/É4 genotype was associated with lower leptin levels. Homozygosity É4/É4 was associated with a more atherogenic lipid profile and possibly dysregulation of leptin and adiponectin signaling in lipid metabolism.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apolipoproteínas E
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Posmenopausia
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Leptina
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Adiponectina
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Lípidos
Límite:
Aged
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Female
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Humans
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Middle aged
País como asunto:
Europa
Idioma:
En
Año:
2017
Tipo del documento:
Article