Circular RNA: a new star in neurological diseases.
Int J Neurosci
; 127(8): 726-734, 2017 Aug.
Article
en En
| MEDLINE
| ID: mdl-27619342
ABSTRACT
Circular RNAs (circRNAs) are novel endogenous non-coding RNAs characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. In this review, we summarize a number of the latest theories regarding the biogenesis, properties and functions of circRNAs. Specifically, we focus on the advancing characteristics and functions of circRNAs in the brain and neurological diseases. CircRNAs exhibit the characteristics of species conservation, abundance and tissue/developmental-stage-specific expression in the brain. We also describe the relationship between circRNAs and several neurological diseases and highlight their functions in neurological diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN
/
Enfermedades del Sistema Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article