Neurodevelopmental outcomes in postnatal growth-restricted preterm infants with postnatal head-sparing.
J Perinatol
; 36(12): 1116-1121, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27629374
ABSTRACT
OBJECTIVE:
To compare neurodevelopmental outcomes in postnatal growth-restricted infants born <29 weeks with and without postnatal head-sparing (PHS). STUDYDESIGN:
We analyzed developmental outcomes at 2 years of age among postnatally growth-restricted infants with and without head-sparing. The primary outcome was Bayley III cognitive composite score; secondary outcomes included Bayley III motor composite score, moderate/severe cerebral palsy, gross motor functional classification scale level⩾2, and presence or absence of neurodevelopmental impairment (NDI).RESULTS:
Of 1098 infants evaluated at 18 to 22 months, 658 were postnatally growth restricted, of whom 301 had head-sparing. In the multivariate model including independent risk factors for poor growth and poor developmental outcome, infants with head-sparing had higher adjusted motor composite scores (mean difference 4.65, P<0.01), but no differences in other neurodevelopmental outcomes.CONCLUSION:
PHS is associated with improved neurodevelopmental outcome in extremely preterm infants, specifically Bayley III motor scores, but whether beneficial effects of PHS persist later in life is unknown.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Desarrollo Infantil
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Discapacidades del Desarrollo
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Recien Nacido Extremadamente Prematuro
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Año:
2016
Tipo del documento:
Article