Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

Banerjee, Mayukh; Marensi, Vanessa; Conseil, Gwenaëlle; Le, X Chris; Cole, Susan P C; Leslie, Elaine M

Banerjee, Mayukh; Marensi, Vanessa; Conseil, Gwenaëlle; Le, X Chris; Cole, Susan P C; Leslie, Elaine M.

Banerjee M; Department of Physiology and Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address: mbanerje@ualberta.ca.
Marensi V; Department of Physiology and Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address: marensi@ualberta.ca.
Conseil G; Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Queen's University, Kingston, ON K7L 3N6, Canada. Electronic address: conseilg@queensu.ca.
Le XC; Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Building, University of Alberta, Edmonton, AB T6G 2G3, Canada. Electronic address: xc.le@ualberta.ca.
Cole SP; Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Queen's University, Kingston, ON K7L 3N6, Canada. Electronic address: spc.cole@queensu.ca.
Leslie EM; Department of Physiology and Membrane Protein Disease Research Group, University of Alberta, Edmonton, AB T6G 2H7, Canada; Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Building, University of Alberta, Edmonton, AB T6G 2G3, Canada. Elect

Biochem Pharmacol ; 120: 72-82, 2016 Nov 15.

Article en En | MEDLINE | ID: mdl-27659809

Asunto(s)

Arsenicales/metabolismo; Dinoprostona/metabolismo; Contaminantes Ambientales/metabolismo; Estradiol/análogos & derivados; Riñón/metabolismo; Proteínas Asociadas a Resistencia a Múltiples Medicamentos/metabolismo; Polimorfismo de Nucleótido Simple; Sustitución de Aminoácidos; Animales; Biotransformación; Ácido Cacodílico/metabolismo; Línea Celular; Estradiol/metabolismo; Glutatión/metabolismo; Células HEK293; Humanos; Proteínas Asociadas a Resistencia a Múltiples Medicamentos/química; Proteínas Asociadas a Resistencia a Múltiples Medicamentos/genética; Mutagénesis Sitio-Dirigida; Mutación; Compuestos Organometálicos/metabolismo; Transporte de Proteínas; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Sus scrofa

Palabras clave

17ß-estradiol 17-(ß-d-glucuronide) (PubChem CID: 443090); ATP-binding cassette transporter; Arsenic; Glutathione; MRP4/ABCC4; Non-synonymous single nucleotide polymorphism; Prostaglandin E(2); dimethylarsinic acid (PubChem CID: 2513); glutathione (PubChem CID: 124886); monomethylarsonous acid (PubChem CID: 161491); prostaglandin E(2) (PubChem CID: 5280360)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsenicales / Dinoprostona / Polimorfismo de Nucleótido Simple / Proteínas Asociadas a Resistencia a Múltiples Medicamentos / Contaminantes Ambientales / Estradiol / Riñón Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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