A Functional Role for Antibodies in Tuberculosis.
Cell
; 167(2): 433-443.e14, 2016 Oct 06.
Article
en En
| MEDLINE
| ID: mdl-27667685
ABSTRACT
While a third of the world carries the burden of tuberculosis, disease control has been hindered by a lack of tools, including a rapid, point-of-care diagnostic and a protective vaccine. In many infectious diseases, antibodies (Abs) are powerful biomarkers and important immune mediators. However, in Mycobacterium tuberculosis (Mtb) infection, a discriminatory or protective role for humoral immunity remains unclear. Using an unbiased antibody profiling approach, we show that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, such that Ltb infection is associated with unique Ab Fc functional profiles, selective binding to FcγRIII, and distinct Ab glycosylation patterns. Moreover, compared to Abs from Atb, Abs from Ltb drove enhanced phagolysosomal maturation, inflammasome activation, and, most importantly, macrophage killing of intracellular Mtb. Combined, these data point to a potential role for Fc-mediated Ab effector functions, tuned via differential glycosylation, in Mtb control.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Interacciones Huésped-Patógeno
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Tuberculosis Latente
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Inmunidad Humoral
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Anticuerpos Antibacterianos
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Mycobacterium tuberculosis
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2016
Tipo del documento:
Article