Sparse activity of identified dentate granule cells during spatial exploration.
Elife
; 52016 10 03.
Article
en En
| MEDLINE
| ID: mdl-27692065
ABSTRACT
In the dentate gyrus - a key component of spatial memory circuits - granule cells (GCs) are known to be morphologically diverse and to display heterogeneous activity profiles during behavior. To resolve structure-function relationships, we juxtacellularly recorded and labeled single GCs in freely moving rats. We found that the vast majority of neurons were silent during exploration. Most active GCs displayed a characteristic spike waveform, fired at low rates and showed spatial activity. Primary dendritic parameters were sufficient for classifying neurons as active or silent with high accuracy. Our data thus support a sparse coding scheme in the dentate gyrus and provide a possible link between structural and functional heterogeneity among the GC population.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Giro Dentado
/
Aprendizaje Espacial
/
Memoria Espacial
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article