Systemically Administered RNAi Molecule Sensitizes Malignant Pleural Mesotheliomal Cells to Pemetrexed Therapy.

Abu Lila, Amr S; Fukushima, Masakazu; Huang, Cheng-Long; Wada, Hiromi; Ishida, Tatsuhiro

Abu Lila, Amr S; Fukushima, Masakazu; Huang, Cheng-Long; Wada, Hiromi; Ishida, Tatsuhiro.

Abu Lila AS; Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University , Tokushima, Japan.
Fukushima M; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University , Zagazig 44519, Egypt.
Huang CL; Department of Pharmaceutics, Faculty of Pharmacy, Hail University , Hail 2440, Saudi Arabia.
Wada H; Department of Cancer Metabolism and Therapy, Institute of Biomedical Sciences, Tokushima University , Tokushima 770-8505, Japan.
Ishida T; Department of Thoracic Surgery, Faculty of Medicine, Kyoto University , Kyoto 606-8501, Japan.

Mol Pharm ; 13(11): 3955-3963, 2016 11 07.

Article en En | MEDLINE | ID: mdl-27740765

Asunto(s)

Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/terapia; Mesotelioma/tratamiento farmacológico; Mesotelioma/terapia; Pemetrexed/uso terapéutico; ARN Interferente Pequeño/genética; Animales; Apoptosis/efectos de los fármacos; Apoptosis/genética; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/genética; Humanos; Liposomas/química; Neoplasias Pulmonares/genética; Masculino; Mesotelioma/genética; Mesotelioma Maligno; Ratones; Ratones Desnudos; Polietilenglicoles/química; Interferencia de ARN; Timidilato Sintasa/genética; Transfección

Palabras clave

PEG-coated shRNA-lipoplex; malignant pleural mesothelioma; pemetrexed; short hairpin RNA; thymidylate synthase

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Banco de datos: MEDLINE Asunto principal: ARN Interferente Pequeño / Pemetrexed / Neoplasias Pulmonares / Mesotelioma Límite: Animals / Humans / Male Idioma: En Año: 2016 Tipo del documento: Article

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