CAND-LO 2014-15 study: changing epidemiology of candidemia in Lombardy (Italy).
Infection
; 44(6): 765-780, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-27753001
ABSTRACT
PURPOSE:
The aim of this study was to monitor recent changes in the epidemiology of candidemia and in the antifungal susceptibility profiles of Candida isolates in one Italian region (Lombardy) in 2014-2015 in comparison with two other studies performed in the same area in 1997-1999 and in 2009.METHODS:
A laboratory-based surveillance was conducted in 11 microbiology laboratories. Identification of Candida isolates from 868 episodes and antifungal susceptibility testing (YeastOne) was performed locally.RESULTS:
A progressive increase in the rate of candidemia up to 1.27/1000 admissions and 1.59/10,000 patient days was documented. In all the three surveys, Candida albicans remains the most frequently isolated species, ranging from 52 to 59 % of the etiology of BSIs. The epidemiological shift to the more resistant C. glabrata, observed between 1997-1999 and 2009 surveys, was not confirmed by our more recent data. The pattern of etiology of BSIs occurred in 2014-2015 overlaps that of the 90s. Acquired antifungal resistance is a rare event. No isolate had an amphoterin B minimal inhibitory concentration (MIC, mg/L) value higher than the epidemiological cutoff. All the echinocandin MIC distributions are typical for wild-type organisms except for those of two C. glabrata isolates. Fluconazole resistance declined from 24.9 % in the 2009 survey to 5.4 % in the recent one.CONCLUSIONS:
Data from regional surveys may highlight the influence of therapeutic practices on the epidemiology of Candida BSIs and may optimize empirical therapies.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Candida
/
Candidemia
Tipo de estudio:
Screening_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
2016
Tipo del documento:
Article