Aryl Hydrocarbon Receptor Ligands in Cigarette Smoke Induce Production of Interleukin-22 to Promote Pancreatic Fibrosis in Models of Chronic Pancreatitis.

Xue, Jing; Zhao, Qinglan; Sharma, Vishal; Nguyen, Linh P; Lee, Yvonne N; Pham, Kim L; Edderkaoui, Mouad; Pandol, Stephen J; Park, Walter; Habtezion, Aida

Xue, Jing; Zhao, Qinglan; Sharma, Vishal; Nguyen, Linh P; Lee, Yvonne N; Pham, Kim L; Edderkaoui, Mouad; Pandol, Stephen J; Park, Walter; Habtezion, Aida.

Xue J; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California. Electronic address: jingxue@
Zhao Q; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Sharma V; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Nguyen LP; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Lee YN; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Pham KL; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Edderkaoui M; Cedars-Sinai Medical Center and Department of Veterans Affairs, Los Angeles, California.
Pandol SJ; Cedars-Sinai Medical Center and Department of Veterans Affairs, Los Angeles, California.
Park W; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
Habtezion A; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California. Electronic address: aidah@stanford.edu.

Gastroenterology ; 151(6): 1206-1217, 2016 12.

Article en En | MEDLINE | ID: mdl-27769811

Asunto(s)

Linfocitos T CD4-Positivos/metabolismo; Interleucinas/metabolismo; Páncreas/patología; Pancreatitis Crónica/inmunología; Pancreatitis Crónica/patología; Receptores de Hidrocarburo de Aril; Actinas/genética; Animales; Anticuerpos/farmacología; Benzo(a)pireno/farmacología; Células Cultivadas; Ceruletida; Colágeno Tipo I/genética; Cadena alfa 1 del Colágeno Tipo I; Modelos Animales de Enfermedad; Fibronectinas/genética; Fibrosis; Expresión Génica/efectos de los fármacos; Humanos; Interferón gamma/metabolismo; Interleucina-17/metabolismo; Interleucinas/genética; Interleucinas/inmunología; Interleucinas/farmacología; Ligandos; Activación de Linfocitos; Ratones; Células Estrelladas Pancreáticas/química; Pancreatitis Crónica/inducido químicamente; Pancreatitis Crónica/metabolismo; Dibenzodioxinas Policloradas/farmacología; Receptores de Hidrocarburo de Aril/agonistas; Receptores de Hidrocarburo de Aril/antagonistas & inhibidores; Receptores de Interleucina/análisis; Humo; Fumar/inmunología; Productos de Tabaco; Factor de Crecimiento Transformador beta/genética; Interleucina-22

Palabras clave

BaP; CP; Immune Regulation; PSC; TCDD

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Páncreas / Linfocitos T CD4-Positivos / Interleucinas / Receptores de Hidrocarburo de Aril / Pancreatitis Crónica Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Año: 2016 Tipo del documento: Article

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