Regulation of Drosophila Brain Wiring by Neuropil Interactions via a Slit-Robo-RPTP Signaling Complex.
Dev Cell
; 39(2): 267-278, 2016 10 24.
Article
en En
| MEDLINE
| ID: mdl-27780041
ABSTRACT
The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of nerve cord patterning. Robo receptors also contribute to wiring brain circuits. Whether molecular mechanisms regulating these signals are modified to fit more complex brain wiring processes is unclear. We investigated the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identified differences in the cellular and molecular mechanisms of Robo/Slit function. First, we find that signaling by Robo receptors in the brain is regulated by the Receptor Protein Tyrosine Phosphatase RPTP69d. RPTP69d increases membrane availability of Robo3 without affecting its phosphorylation state. Second, we detect no midline localization of Slit during brain development. Instead, Slit is enriched in the mushroom body, a neuronal structure covering large areas of the brain. Thus, a divergent molecular mechanism regulates neuronal circuit wiring in the Drosophila brain, partly in response to signals from the mushroom body.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Receptores Inmunológicos
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Transducción de Señal
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Neurópilo
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Proteínas de Drosophila
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Proteínas Tirosina Fosfatasas Similares a Receptores
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Red Nerviosa
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Proteínas del Tejido Nervioso
Límite:
Animals
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Humans
Idioma:
En
Año:
2016
Tipo del documento:
Article