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Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs.
Gil-Cruz, Cristina; Perez-Shibayama, Christian; Onder, Lucas; Chai, Qian; Cupovic, Jovana; Cheng, Hung-Wei; Novkovic, Mario; Lang, Philipp A; Geuking, Markus B; McCoy, Kathy D; Abe, Shinya; Cui, Guangwei; Ikuta, Koichi; Scandella, Elke; Ludewig, Burkhard.
  • Gil-Cruz C; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Perez-Shibayama C; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Onder L; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Chai Q; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Cupovic J; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Cheng HW; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Novkovic M; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
  • Lang PA; Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Germany.
  • Geuking MB; Division of Gastroenterology, Department of Clinical Research, University of Bern, Bern, Switzerland.
  • McCoy KD; Division of Gastroenterology, Department of Clinical Research, University of Bern, Bern, Switzerland.
  • Abe S; Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
  • Cui G; Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ikuta K; Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
  • Scandella E; Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan.
  • Ludewig B; Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Nat Immunol ; 17(12): 1388-1396, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27798617
ABSTRACT
Fibroblastic reticular cells (FRCs) of secondary lymphoid organs form distinct niches for interaction with hematopoietic cells. We found here that production of the cytokine IL-15 by FRCs was essential for the maintenance of group 1 innate lymphoid cells (ILCs) in Peyer's patches and mesenteric lymph nodes. Moreover, FRC-specific ablation of the innate immunological sensing adaptor MyD88 unleashed IL-15 production by FRCs during infection with an enteropathogenic virus, which led to hyperactivation of group 1 ILCs and substantially altered the differentiation of helper T cells. Accelerated clearance of virus by group 1 ILCs precipitated severe intestinal inflammatory disease with commensal dysbiosis, loss of intestinal barrier function and diminished resistance to colonization. In sum, FRCs act as an 'on-demand' immunological 'rheostat' by restraining activation of group 1 ILCs and thereby preventing immunopathological damage in the intestine.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos / Infecciones por Coronavirus / Virus de la Hepatitis Murina / Interleucina-15 / Citrobacter rodentium / Infecciones por Enterobacteriaceae / Fibroblastos Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos / Infecciones por Coronavirus / Virus de la Hepatitis Murina / Interleucina-15 / Citrobacter rodentium / Infecciones por Enterobacteriaceae / Fibroblastos Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article