Neuroimmune interactions: dendritic cell modulation by the sympathetic nervous system.
Semin Immunopathol
; 39(2): 165-176, 2017 02.
Article
en En
| MEDLINE
| ID: mdl-27800584
ABSTRACT
Dendritic cells are of paramount importance bridging innate and adaptive immune responses. Depending on the context, after sensing environmental antigens, commensal microorganisms, pathogenic agents, or antigens from the diet, dendritic cells may drive either different effector adaptive immune responses or tolerance, avoiding tissue damage. Although the plasticity of the immune response and the capacity to regulate itself are considered essential to orchestrate appropriate physiological responses, it is known that the nervous system plays a relevant role controlling immune cell function. Dendritic cells present in the skin, the intestine, and lymphoid organs, besides expressing adrenergic receptors, can be reached by neurotransmitters released by sympathetic fibers innervating these tissues. These review focus on how neurotransmitters from the sympathetic nervous system can modulate dendritic cell function and how this may impact the immune response and immune-mediated disorders.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Simpático
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Células Dendríticas
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Neuroinmunomodulación
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Sistema Inmunológico
Límite:
Animals
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article