Localization of mRNA for the oncotrophoblastic protein oncomodulin during implantation and early placentation in the rat.
Placenta
; 10(4): 359-75, 1989.
Article
en En
| MEDLINE
| ID: mdl-2780516
ABSTRACT
The mRNA for the oncodevelopmental calcium-binding protein oncomodulin (MW 11,700) has been detected in tissues of the rat conceptus by in situ hybridization using biotinylated RNA probes. Oncomodulin mRNA was detected in the basal zone and labyrinth of rat placenta, following a similar distribution to that shown for oncomodulin by immunohistochemistry. Oncomodulin mRNA was also detected in rat ectoplacental cone at ten days and in amnion and PYS, but not VYS from 11 days onward. Previously oncomodulin was not detected embryonically from day 14 to birth, but in the present study of oncomodulin mRNA and protein, both were detected in implantation stages from blastula through egg cylinder. Staining was also present on decidual tissue. The suggestion is made that the oncomodulin gene is initially active in all cell types, but later its activity is confined to extraembryonic tissues.
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Banco de datos:
MEDLINE
Asunto principal:
Implantación del Embrión
/
Placentación
/
Trofoblastos
/
Proteínas de Unión al Calcio
/
ARN Mensajero
/
Proteínas de Neoplasias
Límite:
Animals
/
Pregnancy
Idioma:
En
Año:
1989
Tipo del documento:
Article