Receptor-Mediated Endocytosis in the Proximal Tubule.
Annu Rev Physiol
; 79: 425-448, 2017 02 10.
Article
en En
| MEDLINE
| ID: mdl-27813828
ABSTRACT
Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease. This review describes our current understanding of the endocytic pathway and the multiligand receptors that mediate LMW protein uptake in PT cells, how these are regulated in response to physiologic cues, and the molecular basis of inherited diseases characterized by LMW proteinuria.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Superficie Celular
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Endocitosis
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Túbulos Renales Proximales
Límite:
Animals
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article