At-line determination of pharmaceuticals small molecule's blending end point using chemometric modeling combined with Fourier transform near infrared spectroscopy.

Tewari, Jagdish; Strong, Richard; Boulas, Pierre

Tewari, Jagdish; Strong, Richard; Boulas, Pierre.

Tewari J; Pharmaceutical Analytical Department, Biogen, 115 Broadway, Cambridge, MA 02142, United States. Electronic address: jagdish.tewari@biogen.com.
Strong R; Pharmaceutical Analytical Department, Biogen, 115 Broadway, Cambridge, MA 02142, United States.
Boulas P; Pharmaceutical Analytical Department, Biogen, 115 Broadway, Cambridge, MA 02142, United States.

Spectrochim Acta A Mol Biomol Spectrosc ; 173: 886-891, 2017 Feb 15.

Article en En | MEDLINE | ID: mdl-27816889

Asunto(s)

Modelos Moleculares; Preparaciones Farmacéuticas/análisis; Preparaciones Farmacéuticas/química; Cromatografía Líquida de Alta Presión/métodos; Espectroscopía Infrarroja por Transformada de Fourier/métodos

Palabras clave

Artificial neural network (ANN); Blend uniformity; Chemometric; FT-NIR; Figures of merit; Partial least squares (PLS1, PLS2); Principal component regression (PCR)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Modelos Moleculares Tipo de estudio: Prognostic_studies Idioma: En Año: 2017 Tipo del documento: Article

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