NMR based structural studies decipher stacking of the alkaloid coralyne to terminal guanines at two different sites in parallel G-quadruplex DNA, [d(TTGGGGT)]<sub>4</sub> and [d(TTAGGGT)]<sub>4</sub>.

Padmapriya, Kumar; Barthwal, Ritu

NMR based structural studies decipher stacking of the alkaloid coralyne to terminal guanines at two different sites in parallel G-quadruplex DNA, [d(TTGGGGT)]₄ and [d(TTAGGGT)]₄.

Padmapriya, Kumar; Barthwal, Ritu.

Padmapriya K; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India.
Barthwal R; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, India. Electronic address: ritubfbs@iitr.ac.in.

Biochim Biophys Acta Gen Subj ; 1861(2): 37-48, 2017 Feb.

Article en En | MEDLINE | ID: mdl-27838396

Asunto(s)

Alcaloides/química; Alcaloides de Berberina/química; ADN/química; Guanina/química; Dicroismo Circular; G-Cuádruplex; Enlace de Hidrógeno; Espectroscopía de Resonancia Magnética/métodos; Simulación de Dinámica Molecular; Protones; Telomerasa/química; Telómero/química

Palabras clave

Alkaloid coralyne; Circular dichroism; Nuclear magnetic resonance; Restrained molecular dynamics; Telomeric G-quadruplex DNA; Thermal stabilization

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alcaloides de Berberina / ADN / Alcaloides / Guanina Idioma: En Año: 2017 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Alcaloides de Berberina / ADN / Alcaloides / Guanina Idioma: En Año: 2017 Tipo del documento: Article