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Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Liu, W; Yu, W-M; Zhang, J; Chan, R J; Loh, M L; Zhang, Z; Bunting, K D; Qu, C-K.
  • Liu W; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.
  • Yu WM; Department of Medicine, Division of Hematology/Oncology, Case Western Reserve University, Cleveland, OH, USA.
  • Zhang J; Department of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
  • Chan RJ; Department of Pediatrics, Division of Hematology and Oncology, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, GA, USA.
  • Loh ML; The First Affiliated Hospital, Lanzhou University, Lanzhou, China.
  • Zhang Z; Herman B. Wells Center for Pediatric Research, Indiana University, Indianapolis, IN, USA.
  • Bunting KD; Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of California, San Francisco, CA, USA.
  • Qu CK; The First Affiliated Hospital, Lanzhou University, Lanzhou, China.
Leukemia ; 31(6): 1415-1422, 2017 06.
Article en En | MEDLINE | ID: mdl-27840422
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Serina-Treonina Quinasas TOR / Inhibidores de las Quinasa Fosfoinosítidos-3 / Mutación / Trastornos Mieloproliferativos Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Serina-Treonina Quinasas TOR / Inhibidores de las Quinasa Fosfoinosítidos-3 / Mutación / Trastornos Mieloproliferativos Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article