Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus.
Org Biomol Chem
; 15(1): 61-64, 2016 Dec 20.
Article
en En
| MEDLINE
| ID: mdl-27845468
ABSTRACT
Deuterium and carbon-13 labelled glycerols have been fed to Streptomyces calvus fermentations and isotope incorporation into the fluorine containing antibiotic nucleocidin have been evaluated by 19F-NMR. A single deuterium atom was incorporated from [2H5]- and (R)-[2H2]-glycerol into C-5' of the antibiotic, suggesting that an oxidation occurs at this carbon after ribose ring assembly from glycerol (pentose phosphate pathway), during nucleocidin biosynthesis.
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Banco de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Adenosina
/
Glicerol
/
Antibacterianos
Idioma:
En
Año:
2016
Tipo del documento:
Article