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Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
McGettrick, Anne F; Corcoran, Sarah E; Barry, Paul J G; McFarland, Jennifer; Crès, Cécile; Curtis, Anne M; Franklin, Edward; Corr, Sinéad C; Mok, K Hun; Cummins, Eoin P; Taylor, Cormac T; O'Neill, Luke A J; Nolan, Derek P.
  • McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; mcgettra@tcd.ie denolan@tcd.ie.
  • Corcoran SE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Barry PJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • McFarland J; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Crès C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Curtis AM; Faculty of Medicine and Health Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
  • Franklin E; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Corr SC; Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland.
  • Mok KH; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Cummins EP; School of Medicine and Medical Science, The Conway Institute, University College Dublin, Dublin 4, Ireland.
  • Taylor CT; School of Medicine and Medical Science, The Conway Institute, University College Dublin, Dublin 4, Ireland.
  • O'Neill LA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
  • Nolan DP; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; mcgettra@tcd.ie denolan@tcd.ie.
Proc Natl Acad Sci U S A ; 113(48): E7778-E7787, 2016 11 29.
Article en En | MEDLINE | ID: mdl-27856732
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piruvatos / Trypanosoma brucei brucei / Tripanosomiasis Africana / Subunidad alfa del Factor 1 Inducible por Hipoxia / Inmunidad Innata / Macrófagos Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piruvatos / Trypanosoma brucei brucei / Tripanosomiasis Africana / Subunidad alfa del Factor 1 Inducible por Hipoxia / Inmunidad Innata / Macrófagos Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article