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Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Teh, Charis E; Lalaoui, Najoua; Jain, Reema; Policheni, Antonia N; Heinlein, Melanie; Alvarez-Diaz, Silvia; Sheridan, Julie M; Rieser, Eva; Deuser, Stefanie; Darding, Maurice; Koay, Hui-Fern; Hu, Yifang; Kupresanin, Fiona; O'Reilly, Lorraine A; Godfrey, Dale I; Smyth, Gordon K; Bouillet, Philippe; Strasser, Andreas; Walczak, Henning; Silke, John; Gray, Daniel H D.
  • Teh CE; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Lalaoui N; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Jain R; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Policheni AN; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Heinlein M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Alvarez-Diaz S; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Sheridan JM; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Rieser E; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Deuser S; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Darding M; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Koay HF; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Hu Y; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Kupresanin F; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • O'Reilly LA; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Godfrey DI; Centre for Cell Death, Cancer and Inflammation, University College London, London WC1E 6BT, UK.
  • Smyth GK; Centre for Cell Death, Cancer and Inflammation, University College London, London WC1E 6BT, UK.
  • Bouillet P; Centre for Cell Death, Cancer and Inflammation, University College London, London WC1E 6BT, UK.
  • Strasser A; The Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.
  • Walczak H; The Australian Research Council Centre of Excellence for Advanced Molecular Imaging, The University of Melbourne, Melbourne, Victoria 3052, Australia.
  • Silke J; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
  • Gray DH; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
Nat Commun ; 7: 13353, 2016 11 18.
Article en En | MEDLINE | ID: mdl-27857075
ABSTRACT
The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive immunity is unclear. Here we show that the LUBAC components HOIP, HOIL-1 and SHARPIN have essential roles in late thymocyte differentiation, FOXP3+ regulatory T (Treg)-cell development and Treg cell homeostasis. LUBAC activity is not required to prevent TNF-induced apoptosis or necroptosis but is necessary for the transcriptional programme of the penultimate stage of thymocyte differentiation. Treg cell-specific ablation of HOIP causes severe Treg cell deficiency and lethal immune pathology, revealing an ongoing requirement of LUBAC activity for Treg cell homeostasis. These data reveal stage-specific requirements for LUBAC in coordinating the signals required for T-cell differentiation.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Timo / Linfocitos T / Diferenciación Celular / Ubiquitina / Homeostasis Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Timo / Linfocitos T / Diferenciación Celular / Ubiquitina / Homeostasis Límite: Animals Idioma: En Año: 2016 Tipo del documento: Article