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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Soutter, Holly H; Centrella, Paolo; Clark, Matthew A; Cuozzo, John W; Dumelin, Christoph E; Guie, Marie-Aude; Habeshian, Sevan; Keefe, Anthony D; Kennedy, Kaitlyn M; Sigel, Eric A; Troast, Dawn M; Zhang, Ying; Ferguson, Andrew D; Davies, Gareth; Stead, Eleanor R; Breed, Jason; Madhavapeddi, Prashanti; Read, Jon A.
  • Soutter HH; Therapeutic Discovery Sciences, X-Chem Pharmaceuticals, Waltham, MA 02453; hsoutter@x-chemrx.com Jon.Read@astrazeneca.com.
  • Centrella P; Discovery Chemistry, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Clark MA; X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Cuozzo JW; Therapeutic Discovery Sciences, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Dumelin CE; Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4056 Basel, Switzerland.
  • Guie MA; Scientific Computing, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Habeshian S; Discovery Chemistry, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Keefe AD; Lead Discovery, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Kennedy KM; Discovery Chemistry, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Sigel EA; Scientific Computing, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Troast DM; Morphic Therapeutic, Waltham, MA 02451.
  • Zhang Y; Discovery Chemistry, X-Chem Pharmaceuticals, Waltham, MA 02453.
  • Ferguson AD; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Waltham, MA 02451.
  • Davies G; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Macclesfield SK10 4TG, United Kingdom.
  • Stead ER; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Macclesfield SK10 4TG, United Kingdom.
  • Breed J; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Madhavapeddi P; AstraZeneca India Private Ltd., Hebbal, Bangalore 560 024, India.
  • Read JA; Discovery Sciences, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge CB4 0WG, United Kingdom; hsoutter@x-chemrx.com Jon.Read@astrazeneca.com.
Proc Natl Acad Sci U S A ; 113(49): E7880-E7889, 2016 12 06.
Article en En | MEDLINE | ID: mdl-27864515
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Proteínas Bacterianas / Mycobacterium tuberculosis Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Proteínas Bacterianas / Mycobacterium tuberculosis Idioma: En Año: 2016 Tipo del documento: Article