Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population.
Behav Brain Funct
; 12(1): 30, 2016 Nov 21.
Article
en En
| MEDLINE
| ID: mdl-27871272
ABSTRACT
BACKGROUND:
Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population.METHODS:
Four polymorphisms (rs4570625, rs11178997, rs1386494 and rs7305115) of the TPH-2 gene were analyzed by using polymerase chain reaction and DNA microarray hybridization in a case-control study of 276 Han Chinese individuals (124 ODD and 152 controls).RESULTS:
In single marker analyses,there was a significant difference in the genotype (χ 2 = 4.163, P = 0.041) and allele frequency (χ 2 = 3.930, P = 0.047) of rs1386494 between ODD and control groups. Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups.CONCLUSIONS:
These findings suggest the role of these TPH-2 gene variants in susceptibility to ODD. Some haplotypes might be the risk factors for Chinese Han children with ODD, while others might be preventable factors.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triptófano Hidroxilasa
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Déficit de la Atención y Trastornos de Conducta Disruptiva
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
País como asunto:
Asia
Idioma:
En
Año:
2016
Tipo del documento:
Article