Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis.
Blood
; 129(4): 420-423, 2017 01 26.
Article
en En
| MEDLINE
| ID: mdl-27903530
ABSTRACT
Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into 2 subtypes near-haploid ALL with 24 to 30 chromosomes and low-hypodiploid ALL with 31 to 39 chromosomes. Both groups are associated with a very poor prognosis, and these patients are among those who could benefit most from novel treatments.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucemia-Linfoma Linfoblástico de Células Precursoras
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Genotipo
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Haploidia
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Aneuploidia
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2017
Tipo del documento:
Article