Primary cilia: a link between hormone signalling and endocrine-related cancers?

O'Toole, Samuel M; Chapple, J Paul

O'Toole, Samuel M; Chapple, J Paul.

O'Toole SM; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.
Chapple JP; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.

Biochem Soc Trans ; 44(5): 1227-1234, 2016 10 15.

Article en En | MEDLINE | ID: mdl-27911704

ABSTRACT

ABSTRACT

Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes to tumourigenesis. This review considers the role of primary cilia in the pathogenesis of endocrine-related cancers.

Asunto(s)

Cilios/metabolismo; Hormonas/metabolismo; Neoplasias/metabolismo; Transducción de Señal; Animales; Axonema/metabolismo; Cuerpos Basales/metabolismo; Cilios/patología; Neoplasias de las Glándulas Endocrinas/metabolismo; Neoplasias de las Glándulas Endocrinas/patología; Humanos; Modelos Biológicos; Neoplasias/patología

Palabras clave

Von HippelLindau; breast cancers; cilia; endocrine cancer; ovarian cancer; prostate cancer

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Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Cilios / Hormonas / Neoplasias Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article

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PubMed Links

Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Cilios / Hormonas / Neoplasias Límite: Animals / Humans Idioma: En Año: 2016 Tipo del documento: Article