Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus.
PLoS One
; 11(12): e0162608, 2016.
Article
en En
| MEDLINE
| ID: mdl-27935938
ABSTRACT
PURPOSE:
In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.METHODS:
This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.RESULTS:
In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768).CONCLUSION:
In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Retina
/
Vasos Retinianos
/
Capilares
/
Diabetes Mellitus Tipo 2
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Screening_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
2016
Tipo del documento:
Article