Clinical significance of Wip1 overexpression and its association with the p38MAPK/p53/p16 pathway in NSCLC.
Mol Med Rep
; 15(2): 719-723, 2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-27959454
ABSTRACT
Wip1 is deregulated in numerous human malignancies. However, its roles in nonsmall cell lung cancer (NSCLC) remain unclear. In the current study, the expression of Wip1 was investigated in NSCLC and its clinical significance was detected. Immunohistochemical staining was used to measure the expression of (wildtype p53 induced phosphatase 1) Wip1, p38 mitogenactivated protein kinase (MAPK), p53, p16 protein in a group of 60 NSCLC and 20 normal lung tissues. In addition, western blotting was performed to detect the Wip1 protein in fresh tissues. The correlations between clinical characteristics and Wip1 expression were analyzed using SPSS, version 16.0 software. The expression of Wip1 was positive in 63.3% (38/60) of NSCLC tissues, and in none of the normal lung tissues (0/20; P<0.01). In addition, Wip1 overexpression was significantly associated with tumor length and differentiation (P=0.008 and 0.03, respectively). The expression of Wip1 was negatively correlated with that of p38MAPK, p53 and p16 (r=0.284, 0.352 and 0.348, respectively). The results of the current study demonstrated that Wip1 was frequently overexpressed in NSCLC, which may serve an essential role in the p38MAPK/p53/p16 signaling pathway.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteína p53 Supresora de Tumor
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Carcinoma de Pulmón de Células no Pequeñas
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Inhibidor p16 de la Quinasa Dependiente de Ciclina
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Proteínas Quinasas p38 Activadas por Mitógenos
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Proteína Fosfatasa 2C
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Neoplasias Pulmonares
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2017
Tipo del documento:
Article