Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.
Saudi J Gastroenterol
; 22(6): 448-455, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-27976641
ABSTRACT
BACKGROUND/AIMS:
Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice. PATIENTS ANDMETHODS:
In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin. Then a mouse model with Dextran sulfate sodium sulfate (DSS)-induced ulcerative colitis was constructed, and the effects of deoxyschizandrin on mouse colon inflammation, apoptosis, and CD4 T lymphocyte infiltration in ulcerative colitis were examined.RESULT:
Deoxyschizandrin could improve the symptoms of ulcerative colitis, determined by hematoxylin-eosin (HE) staining and histopathological scores. Moreover, deoxyschizandrin reduced the levels of inflammatory cytokines, suppressed CD4 T cell infiltration, and effectively inhibited apoptosis in the colon of DSS-induced ulcerative colitis mice.CONCLUSION:
In summary, deoxyschizandrin can effectively rescue the symptoms of DSS-induced ulcerative colitis in mice by inhibiting inflammation. T cell infiltration and apoptosis in the colon, suggesting that deoxyschizandrin could be a potential drug in treating ulcerative colitis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
/
Linfocitos T CD4-Positivos
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Colitis Ulcerosa
/
Sulfato de Dextran
/
Lignanos
/
Ciclooctanos
/
Antiinflamatorios
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article