The Lipidâ
A from Rhodopseudomonas palustris Strain BisA53 LPS Possesses a Unique Structure and Low Immunostimulant Properties.
Chemistry
; 23(15): 3637-3647, 2017 Mar 13.
Article
en En
| MEDLINE
| ID: mdl-28004420
ABSTRACT
The search for novel lipidâ
A analogues from any biological source that can act as antagonists, displaying inhibitory activity towards the production of pro-inflammatory cytokines, or as immunomodulators in mammals, is a very topical issue. To this aim, the structure and immunological properties of the lipopolysaccharide lipidâ
A from the purple nonsulfur bacterium Rhodopseudomonas palustris strain BisA53 have been determined. This lipidâ
A displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide Manp-α-(1â4)-GlcpN3N-ß-1â6-GlcpN3N-α-(1â1)-α-GalpA, and four primary amide-linked 140(3-OH) and, as secondary O-acyl substituents, a 160 and the very long-chain fatty acid 260(25-OAc), appended on the GlcpN3N units. This lipidâ
A architecture is definitely rare, so far identified only in the genus Bradyrhizobium. Immunological tests on both murine bone-marrow-derived and human monocyte-derived macrophages revealed an extremely low immunostimulant capability of this LPS lipidâ
A.
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Banco de datos:
MEDLINE
Asunto principal:
Rhodopseudomonas
/
Adyuvantes Inmunológicos
/
Lípido A
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article