Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression.
J Antimicrob Chemother
; 72(4): 1147-1151, 2017 04 01.
Article
en En
| MEDLINE
| ID: mdl-28039275
ABSTRACT
Background:
Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure.Objectives:
We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children.Methods:
Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA.Results:
Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified.Conclusions:
Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos Anti-VIH
/
Infecciones por VIH
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VIH-1
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Transmisión Vertical de Enfermedad Infecciosa
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Carga Viral
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Año:
2017
Tipo del documento:
Article