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Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.
Castanha, Priscila M S; Nascimento, Eduardo J M; Braga, Cynthia; Cordeiro, Marli T; de Carvalho, Otávio V; de Mendonça, Leila R; Azevedo, Elisa A N; França, Rafael F O; Dhalia, Rafael; Marques, Ernesto T A.
  • Castanha PMS; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
  • Nascimento EJM; Faculty of Medical Science/ Institute of Biological Science, University of Pernambuco, Recife, Brazil.
  • Braga C; Center for Vaccine Research, University of Pittsburgh, Pennsylvania, USA.
  • Cordeiro MT; Department of Infectious Disease and Microbiology, University of Pittsburgh, Pennsylvania, USA.
  • de Carvalho OV; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
  • de Mendonça LR; Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil.
  • Azevedo EAN; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
  • França RFO; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
  • Dhalia R; Universidade Federal de Viçosa, Minas Gerais, Brazil.
  • Marques ETA; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Brazil.
J Infect Dis ; 215(5): 781-785, 2017 03 01.
Article en En | MEDLINE | ID: mdl-28039355
ABSTRACT
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acrecentamiento Dependiente de Anticuerpo / Virus del Dengue / Virus Zika / Infección por el Virus Zika / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies Límite: Female / Humans / Pregnancy País como asunto: America do sul / Brasil Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acrecentamiento Dependiente de Anticuerpo / Virus del Dengue / Virus Zika / Infección por el Virus Zika / Anticuerpos Antivirales Tipo de estudio: Prognostic_studies Límite: Female / Humans / Pregnancy País como asunto: America do sul / Brasil Idioma: En Año: 2017 Tipo del documento: Article