Dengue Virus-Specific Antibodies Enhance Brazilian Zika Virus Infection.
J Infect Dis
; 215(5): 781-785, 2017 03 01.
Article
en En
| MEDLINE
| ID: mdl-28039355
ABSTRACT
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Acrecentamiento Dependiente de Anticuerpo
/
Virus del Dengue
/
Virus Zika
/
Infección por el Virus Zika
/
Anticuerpos Antivirales
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Pregnancy
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2017
Tipo del documento:
Article