Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Nat Rev Mol Cell Biol
; 18(3): 159-174, 2017 03.
Article
en En
| MEDLINE
| ID: mdl-28053348
ABSTRACT
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at genomic response elements. In turn, evidence suggests that context-driven plasticity is conferred by the integration of multiple signals, each serving as an allosteric effector of GR conformation, a key determinant of regulatory complex composition and activity. This structural and mechanistic perspective on GR regulatory specificity is likely to extend to other eukaryotic TRFs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Glucocorticoides
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article