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Zika Virus Causing Encephalomyelitis Associated With Immunoactivation.
Galliez, Rafael Mello; Spitz, Mariana; Rafful, Patricia Piazza; Cagy, Marcelo; Escosteguy, Claudia; Germano, Caroline Spósito Brito; Sasse, Elisa; Gonçalves, Alessandro Luis; Silveira, Paola Paz; Pezzuto, Paula; Ornelas, Alice Maria de Magalhães; Tanuri, Amilcar; Aguiar, Renato Santana; Moll, Fernanda Tovar.
  • Galliez RM; Instituto Estadual de Infectologia São Sebastião, Rio de Janeiro, Brazil;; Programa de Pós-Graduação em Clínica Médica da Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Spitz M; University of the State of Rio de Janeiro, Brazil;; Neurology Service and.
  • Rafful PP; Epidemiology Service, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;; D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
  • Cagy M; University of the State of Rio de Janeiro, Brazil;; Neurology Service and.
  • Escosteguy C; Epidemiology Service, Hospital Federal dos Servidores do Estado , Rio de Janeiro , Brazil.
  • Germano CS; University of the State of Rio de Janeiro, Brazil;; Neurology Service and.
  • Sasse E; University of the State of Rio de Janeiro, Brazil;; Neurology Service and.
  • Gonçalves AL; Genetics Department, Biology Institute , and.
  • Silveira PP; Genetics Department, Biology Institute , and.
  • Pezzuto P; Genetics Department, Biology Institute , and.
  • Ornelas AM; Genetics Department, Biology Institute , and.
  • Tanuri A; Genetics Department, Biology Institute , and.
  • Aguiar RS; Genetics Department, Biology Institute , and.
  • Moll FT; Epidemiology Service, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil;; Radiology Department, and.
Open Forum Infect Dis ; 3(4): ofw203, 2016 Oct.
Article en En | MEDLINE | ID: mdl-28053996
ABSTRACT
Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Año: 2016 Tipo del documento: Article