About the complexity of adult onset Still's disease
and advances still required for its management.
BMC Med
; 15(1): 5, 2017 Jan 06.
Article
en En
| MEDLINE
| ID: mdl-28056958
ABSTRACT
Adult onset Still's disease (AOSD) is a rare inflammatory disorder that remains poorly understood. Its pathophysiology is yet to be completely elucidated, but is known to consist mainly on a cytokine cascade, responsible for the systemic manifestations. AOSD diagnosis is usually difficult and delayed, with physicians having to rule out several other conditions, including cancer or infectious diseases. Prognosis is heterogeneous and difficult to establish, ranging from benign outcome to chronic destructive polyarthritis and/or life-threatening events. In addition, treatment remains to be codified, especially considering the development of new drugs. In this commentary, we attempt to elucidate the complexity of AOSD and to highlight the need of working on prognostic tools for this disorder. We also discuss the numerous advances that would be useful for patients in the daily management of this disease.Please see related article http//bmcmedicine.biomedcentral.com/articles/ 10.1186/s12916-016-0738-8 .
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terapia Biológica
/
Citocinas
/
Enfermedad de Still del Adulto
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article