Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer.
Cancer Res
; 77(2): 227-233, 2017 01 15.
Article
en En
| MEDLINE
| ID: mdl-28062403
ABSTRACT
Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies. Cancer Res; 77(2); 227-33. ©2017 AACR.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cromatina
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Regulación Neoplásica de la Expresión Génica
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Transformación Celular Neoplásica
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Epigénesis Genética
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Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article