Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10.
Nat Immunol
; 18(3): 313-320, 2017 03.
Article
en En
| MEDLINE
| ID: mdl-28068307
ABSTRACT
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3-/- mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
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Diferenciación Celular
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Proteínas Serina-Treonina Quinasas
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Centro Germinal
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Linaje de la Célula
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Secretasas de la Proteína Precursora del Amiloide
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Inmunidad Adaptativa
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Proteína ADAM10
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Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article