High VEGFR1/2 expression levels are predictors of poor survival in patients with cervical cancer.
Medicine (Baltimore)
; 96(1): e5772, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-28072723
ABSTRACT
The aim of the study to evaluate the prognostic significance of vascular endothelial growth factor receptor 1 and 2 (VEGFR1/2) expression levels and to correlate these levels with clinicopathological parameters in patients with cervical cancer.Forty-two patients with International Federation of Gynecology and Obstetrics Stage IIB-IVB cervical cancer were analyzed between January 2011 and December 2012. RNA expression levels of VEGFR1/2 were assessed by branched DNA-liquidchip technology and immunohistochemistry. Associations between RNA expression levels, important clinicopathological parameters, and patient survival were statistically evaluated.Higher VEGFR1/2 expression levels were predictive of poor overall survival (Pâ=â0.009 and Pâ=â0.024, respectively). Patients with higher VEGFR1 expression levels were associated with poorer progression-free survival than those with lower VEGFR1 expression levels (Pâ=â0.043). In addition, patients with higher VEGFR1 expression levels were more likely to develop distant metastases than those with lower VEGFR1 expression levels (Pâ=â0.049). Higher VEGFR2 expression levels were associated with larger tumor size (Pâ=â0.037).VEGFR1/2 expression levels were prognostic factors for patients with cervical cancer. Higher VEGFR1/2 expression levels were also predictive of poor overall survival.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Expresión Génica
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Neoplasias del Cuello Uterino
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Receptor 1 de Factores de Crecimiento Endotelial Vascular
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Receptor 2 de Factores de Crecimiento Endotelial Vascular
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article