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Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.
Yang, Hung-Wei; Ye, Ling; Guo, Xin Dong; Yang, Chinglai; Compans, Richard W; Prausnitz, Mark R.
  • Yang HW; Institute of Medical Science and Technology, National Sun Yat-sen University, 70 Lienhai Rd., Kaohsiung, 80424, Taiwan, R.O.C.
  • Ye L; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.
  • Guo XD; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
  • Yang C; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA, 30332, USA.
  • Compans RW; College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuandong Road, Chaoyang District, Beijing, China.
  • Prausnitz MR; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA, 30322, USA.
Adv Healthc Mater ; 6(1)2017 Jan.
Article en En | MEDLINE | ID: mdl-28075069
ABSTRACT
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Poliglutámico / Ácido Poliglicólico / Polilisina / Ácido Láctico / Vacunas de ADN / Vacunas contra el Virus del Ébola / Nanopartículas Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácido Poliglutámico / Ácido Poliglicólico / Polilisina / Ácido Láctico / Vacunas de ADN / Vacunas contra el Virus del Ébola / Nanopartículas Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article