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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.
Sun, Yu; Alberta, John A; Pilarz, Catherine; Calligaris, David; Chadwick, Emily J; Ramkissoon, Shakti H; Ramkissoon, Lori A; Garcia, Veronica Matia; Mazzola, Emanuele; Goumnerova, Liliana; Kane, Michael; Yao, Zhan; Kieran, Mark W; Ligon, Keith L; Hahn, William C; Garraway, Levi A; Rosen, Neal; Gray, Nathanael S; Agar, Nathalie Y; Buhrlage, Sara J; Segal, Rosalind A; Stiles, Charles D.
  • Sun Y; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Alberta JA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Pilarz C; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Calligaris D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Chadwick EJ; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Ramkissoon SH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Ramkissoon LA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Garcia VM; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Mazzola E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Goumnerova L; Center for Molecular Oncologic Pathology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Kane M; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Yao Z; Center for Molecular Oncologic Pathology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Kieran MW; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Ligon KL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Hahn WC; Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Garraway LA; Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Rosen N; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
  • Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Agar NY; Program in Molecular Pharmacology, Department of Medicine, and Center for Mechanism Based Therapeutics Memorial Sloan Kettering Cancer Center, New York, USA.
  • Buhrlage SJ; Division of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.
  • Segal RA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Stiles CD; Center for Molecular Oncologic Pathology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Neuro Oncol ; 19(6): 774-785, 2017 06 01.
Article en En | MEDLINE | ID: mdl-28082416
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Proteínas de Fusión Oncogénica / Quinasas raf / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Multimerización de Proteína / Compuestos Heterocíclicos con 3 Anillos Límite: Animals / Child / Humans / Male Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Proteínas de Fusión Oncogénica / Quinasas raf / Proteínas Proto-Oncogénicas B-raf / Inhibidores de Proteínas Quinasas / Multimerización de Proteína / Compuestos Heterocíclicos con 3 Anillos Límite: Animals / Child / Humans / Male Idioma: En Año: 2017 Tipo del documento: Article