Synthesis and antitumor activity evaluation of novel oleanolic acid derivatives.
J Asian Nat Prod Res
; 19(10): 1000-1010, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28140665
ABSTRACT
Ten novel oleanolic acid (OA) derivatives were synthesized through modifications at positions of A ring and C-28. Inhibitory activities of the oleanolic acid derivatives against SGC7901 and A549 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines. Among them, II4 and II5 exhibited excellent antitumor activities against SGC7901 cells and A549 cells, compared with gefitinib. Molecular docking studies have shown that compounds II4 and II5 produce potent antitumor activities by interacting with C-kit receptor through hydrogen bonds and hydrophobic bonds.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ácido Oleanólico
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Triterpenos Pentacíclicos
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article