Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.
Sci Rep
; 7: 41537, 2017 02 03.
Article
en En
| MEDLINE
| ID: mdl-28155869
ABSTRACT
Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9-15 days after infection, with circulating virus undetectable by day 15-17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
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Fiebre Hemorrágica Ebola
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Ebolavirus
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Profilaxis Posexposición
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Anticuerpos Antivirales
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Antígenos Virales
Límite:
Animals
Idioma:
En
Año:
2017
Tipo del documento:
Article