Clustering of 770,000 genomes reveals post-colonial population structure of North America.
Nat Commun
; 8: 14238, 2017 02 07.
Article
en En
| MEDLINE
| ID: mdl-28169989
ABSTRACT
Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Población
/
Dinámica Poblacional
/
Demografía
/
Genética de Población
Tipo de estudio:
Prognostic_studies
Límite:
Humans
País como asunto:
America do norte
Idioma:
En
Año:
2017
Tipo del documento:
Article