Multiple Functions and Regulation of Mammalian Peroxiredoxins.
Annu Rev Biochem
; 86: 749-775, 2017 06 20.
Article
en En
| MEDLINE
| ID: mdl-28226215
ABSTRACT
Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at various intracellular locations where it can serve as a signaling molecule. Given that Prxs are abundant and possess a structure that renders the cysteine (Cys) residue at the active site highly sensitive to oxidation by H2O2, the signaling function of this oxidant requires extensive and highly localized regulation. Recent findings on the reversible regulation of PrxI through phosphorylation at the centrosome and on the hyperoxidation of the Cys at the active site of PrxIII in mitochondria are described in this review as examples of such local regulation of H2O2 signaling. Moreover, their high affinity for and sensitivity to oxidation by H2O2 confer on Prxs the ability to serve as sensors and transducers of H2O2 signaling through transfer of their oxidation state to bound effector proteins.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Regulación de la Expresión Génica
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Ritmo Circadiano
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Peroxirredoxinas
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Peróxido de Hidrógeno
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Mitocondrias
Límite:
Animals
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article