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Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
Ler, Lian Dee; Ghosh, Sujoy; Chai, Xiaoran; Thike, Aye Aye; Heng, Hong Lee; Siew, Ee Yan; Dey, Sucharita; Koh, Liang Kai; Lim, Jing Quan; Lim, Weng Khong; Myint, Swe Swe; Loh, Jia Liang; Ong, Pauline; Sam, Xin Xiu; Huang, Dachuan; Lim, Tony; Tan, Puay Hoon; Nagarajan, Sanjanaa; Cheng, Christopher Wai Sam; Ho, Henry; Ng, Lay Guat; Yuen, John; Lin, Po-Hung; Chuang, Cheng-Keng; Chang, Ying-Hsu; Weng, Wen-Hui; Rozen, Steven G; Tan, Patrick; Creasy, Caretha L; Pang, See-Tong; McCabe, Michael T; Poon, Song Ling; Teh, Bin Tean.
  • Ler LD; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Ghosh S; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Chai X; NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, Singapore 117456, Singapore.
  • Thike AA; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Heng HL; Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Siew EY; Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.
  • Dey S; Department of Pathology, Singapore General Hospital, Singapore, Singapore.
  • Koh LK; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Lim JQ; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Lim WK; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Myint SS; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Loh JL; Cancer Science Institute of Singapore, National University of Singapore, Centre for Life Sciences, Singapore 117456, Singapore.
  • Ong P; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Sam XX; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Huang D; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Lim T; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Tan PH; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Nagarajan S; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Cheng CW; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Ho H; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Ng LG; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Yuen J; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Lin PH; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Chuang CK; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Chang YH; Department of Pathology, Singapore General Hospital, Singapore, Singapore.
  • Weng WH; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • Rozen SG; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Tan P; Department of Pathology, Singapore General Hospital, Singapore, Singapore.
  • Creasy CL; Department of Pathology, Singapore General Hospital, Singapore, Singapore.
  • Pang ST; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore.
  • McCabe MT; Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Poon SL; Department of Urology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
  • Teh BT; Department of Urology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
Sci Transl Med ; 9(378)2017 02 22.
Article en En | MEDLINE | ID: mdl-28228601
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Neoplasias de la Vejiga Urinaria / Proteínas Nucleares / Histona Demetilasas / Complejo Represivo Polycomb 2 / Proteína Potenciadora del Homólogo Zeste 2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transcripción Genética / Neoplasias de la Vejiga Urinaria / Proteínas Nucleares / Histona Demetilasas / Complejo Represivo Polycomb 2 / Proteína Potenciadora del Homólogo Zeste 2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article