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Blastic transformation of juvenile myelomonocytic leukemia caused by the copy number gain of oncogenic KRAS.
Osumi, Tomoo; Kato, Motohiro; Ouchi-Uchiyama, Meri; Tomizawa, Daisuke; Kataoka, Keisuke; Fujii, Yoichi; Seki, Masafumi; Takita, Junko; Ogawa, Seishi; Uchiyama, Toru; Ohki, Kentaro; Kiyokawa, Nobutaka.
  • Osumi T; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Kato M; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Ouchi-Uchiyama M; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Tomizawa D; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Kataoka K; Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
  • Fujii Y; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Seki M; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Takita J; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ogawa S; Department of Pediatrics, the University of Tokyo, Tokyo, Japan.
  • Uchiyama T; Department of Pediatrics, the University of Tokyo, Tokyo, Japan.
  • Ohki K; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kiyokawa N; Department of Human Genetics, National Research Institute for Child Health and Development, Tokyo, Japan.
Pediatr Blood Cancer ; 64(9)2017 Sep.
Article en En | MEDLINE | ID: mdl-28244637
ABSTRACT
Previous studies have reported several cases of juvenile myelomonocytic leukemia (JMML) developing blastic transformation during an indolent clinical course, but the underlying mechanism of transformation is still not well understood. In this report, we describe a case of JMML with blastic transformation possibly caused by additional copy number gains of the KRAS mutant allele. We have discovered that the copy number gain of the mutant allele is an additional possible cause of blastic transformation in JMML.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Proteínas Proto-Oncogénicas p21(ras) / Dosificación de Gen / Leucemia Mielomonocítica Juvenil Límite: Female / Humans / Infant Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Proteínas Proto-Oncogénicas p21(ras) / Dosificación de Gen / Leucemia Mielomonocítica Juvenil Límite: Female / Humans / Infant Idioma: En Año: 2017 Tipo del documento: Article