A General Asymmetric Synthesis of (R)-Matsutakeol and Flavored Analogs.
Molecules
; 22(3)2017 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-28264452
ABSTRACT
An efficient and practical synthetic route toward chiral matsutakeol and analogs was developed by asymmetric addition of terminal alkyne to aldehydes. (R)-matsutakeol and other flavored substances were feasibly synthesized from various alkylaldehydes in high yield (up to 49.5%, in three steps) and excellent enantiomeric excess (up to >99%). The protocols may serve as an alternative asymmetric synthetic method for active small-molecule library of natural fatty acid metabolites and analogs. These chiral allyl alcohols are prepared for food analysis and screening insect attractants.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alcoholes
/
Aldehídos
/
Alquinos
Tipo de estudio:
Guideline
Idioma:
En
Año:
2017
Tipo del documento:
Article